Taste Mask Orodispersible Tablet of Metronidazole

Taste Mask Orodispersible Tablet of Metronidazole

PAPERBACK

22 Mar, 2012

By Anupam Jain (author), Suresh Kumar Sahu (author), Aditya Nath Pandey (author)

Patients who have problems in swallowing encounter difficulties in taking tablets, particularly pediatric and geriatric patients. Such problems can be reso...

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Last updated on 12 Jan, 2026

ISBN-10:

3848442973

ISBN-13:

9783848442973

Publisher

KS Omniscriptum Publishing

Dimensions

9.00 X 6.00 X 0.21 inches

Language

English

Description

Patients who have problems in swallowing encounter difficulties in taking tablets, particularly pediatric and geriatric patients. Such problems can be resolved by means of orodispersible tablets. These tablets disintegrate instantaneously when put on tongue, releasing the drug that dissolves or disperses in the saliva.Metronidazole is active against a wide variety of anaerobic protozoal parasites and anaerobic bacteria.The present study aim to prepare tablets that can rapidly disintegrate in oral cavity (orodispersible), another challenge with this model drug is to mask the bitter taste. Taste masking was achieved by using aminoalkyl methacrylate copolymer (Eudragit E-100) in the different ratio (1:2 and 1:3) by extrusion technique. The IR shows that there was no significant evidence for interaction between drug and polymers. Six formulations were prepared using taste masked granules and different disintegrants (LH-11) and Avicel PH-102 by varying concentration.

Product Details

ISBN-10

:3848442973

ISBN-13

:9783848442973

Publisher

:KS Omniscriptum Publishing

Publication date

: 22 Mar, 2012

Category

: Medical

Sub-Category

: Pharmacology

Format

:PAPERBACK

Language

:English

Reading Level

: All

Dimension

: 9.00 X 6.00 X 0.21 inches

Weight

:141 g

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